منابع مشابه
Structure of a left-handed DNA G-quadruplex.
Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR soluti...
متن کاملA nanomotor involves a metastable, left-handed DNA duplex.
A newly designed metastable left-handed DNA architecture has been successfully used to power a DNA nanomotor by strand displacement without a toehold.
متن کاملپرده صماخ و چپ دستها T.M and left handed
ABCTRACT: To find out what percentage of the men are left-handed or as a rule use their left hand for writing or do precise or complicated jobs is to question them directly. Neurologists believe that less than 10 percent of people are left - handed. In our study, we should like to know the correct percentage of the men living in Rasht are left -handed . This study is statistically based on m...
متن کاملAlzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form.
Herein we report that Aβ aggregates, not Aβ monomer, can convert Z-DNA back to B-form, and curcumin, a well-known Aβ aggregation inhibitor, can stop DNA Z-B transition studied by means of biophysical and biochemical methods.
متن کاملOne left-handed strand in DNA-oligonucleotide complexes?
A single strand of oligonucleotide can bind to double helical DNA under certain conditions. This must involve some unwinding of the original double helix in a process leading to the formation of a three-stranded region. The free energy for such an entropically unlikely reaction may come from a change in the degree of supercoiling of the original DNA. The conformation of the triple strand is inv...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2015
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-014-8278-6